Genetic Drift

Bioinformatics, Data Science

#note Population Genetics A Concise Guide (18)

This is a note for the book Population Genetics: A Concise Guide (Second Edition). Page 31 Problem 2.9 Graph -ΔNH and ΔuH as function of H for N = 104 and u = 5×10-5. Do the lines intersect where you expect them to? Note: Output: In this situation, 4Nu = 4×104×10-5 = 2, when H > […]

Bioinformatics, Data Science

#note Population Genetics A Concise Guide (17)

This is a note for the book Population Genetics: A Concise Guide (Second Edition). Page 30 Problem 2.8 Graph Equation 2.7 as a function of 4Nu. What value of 4Nu gives a reasonable fit to the average heterozygosity for proteins as described by electrophoretic studies in humans? Note: Equation 2.7: Set t = 4Nu Output: Proteins

Bioinformatics, Data Science

#note Population Genetics A Concise Guide (15)

This is a note for the book Population Genetics: A Concise Guide (Second Edition). Page 28 Problem 2.6 g is almost the same as the homozygosity of the population, G. Suppose we were to define the homozygosity of a population as the probability that two alleles chosen at random from the population with replacement are identical

Bioinformatics, Data Science

#note Population Genetics A Concise Guide (14)

This is a note for the book Population Genetics: A Concise Guide (Second Edition). Page 28 Problem 2.5 Graph simultaneously both Formula 2.4 and Formula 2.5 as a function of N for N from 1 to 100. Is the approximation to your liking? Formula 2.4 Formula 2.5 Code: Output: So we can trust that Formula 2.5

Bioinformatics, Data Science

#note Population Genetics A Concise Guide (13)

This is a note for the book Population Genetics: A Concise Guide (Second Edition). Page 27 Problem 2.4 Graph Ht and Gt for 100 generations with H0 = 1 and population sizes of 1, 10, 100, and 1,000,000. Note: According to the formula: Output: This indicates that genetic drift has a greater impact on small populations

Bioinformatics, Data Science

#note Population Genetics A Concise Guide (11)

Page 24 Problem 2.2 If you know how to program a computer, write a simulation of genetic drift. Note: The simulation model: 1. Choose an allele at random from among the 2N (N is the number of the diploid individuals) alleles in the parent generation. 2. Make an exact copy of the allele. 3. Place

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